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1/18/2024 0 Comments Benchmark scenic construction![]() The SCENIC+ motif collection includes 34,524 unique motifs gathered from 29 motif collections, which were clustered with a two-step strategy. d, Workflow to create motif databases for SCENIC+. Promoter regions were excluded from the analysis. The AUC value is scaled by dividing by the maximum possible AUC at 10% of the ranking. c, Bar-plots showing the area under the recovery curve (AUC enhancer recovery) on the top 10% of the ranking based on STARR-seq signal, for the top 5,000 DARs identified by Signac, pycisTopic and ArchR and top 5,000 regions from the cell-line-specific topics identified by pycisTopic. b, Running-time comparison per topic model using cisTopic with Collapsed Gibbs Sampling or WarpLDA (blue) and pycisTopic with Collapsed Gibbs Sampling or MALLET (red) for parameter optimization. PWM, position weight matrix UCSC, University of California, Santa Cruz. SCENIC+ integrates region accessibility, TF and target gene expression and cistromes to infer eGRNs, in which TFs are linked to their target regions and these to their target genes. Topics and DARs inferred with pycisTopic are transformed into cistromes of directly bound regions by identifying modules that present significant enrichment of the regulator’s binding motif using pycisTarget. Here, we developed SCENIC+, a computational framework that combines single-cell chromatin accessibility and gene expression data with motif discovery to infer enhancer-driven GRNs (eGRNs).Ī, SCENIC+ workflow. In fact, genomic regions that are specifically accessible in a cell type often represent enhancers and are enriched for TFBS combinations 2, 14, 16, 17, 18. With single-cell chromatin-accessibility data, the accuracy of TFBS predictions can be improved substantially 15. For example, SCENIC combines single-cell RNA-sequencing (scRNA-seq) coexpression networks with TF motif discovery 11, 12, but it cannot identify the exact CRE targeted by the TF and it only uses a small proportion of a gene’s putative regulatory space 13, 14. Alternative approaches have recently been described that have increased cellular resolution (for example, single-cell CUT&Tag 6, nano-CT 7 and NTT-seq 8) or that rely on genetic tagging (for example, DamID 9 and nanoDam 10), yet such methods are still difficult to scale to all TFs.Ĭomputational modeling is an alternative for identifying TFBSs. In addition, for most TFs, high-quality antibodies are lacking. Nevertheless, for tissues with high cell-type diversity it remains challenging to map TFBSs because of the need for large amounts of homogenous cells. In-depth knowledge of GRNs is important for mechanistic understanding of biological aspects underlying development 1, 2, evolution 3, 4 and disease 5 however, knowledge of TF–target relationships at the cis-regulatory level is still limited.Įxperimental techniques, including chromatin immunoprecipitation and sequencing (ChIP-seq), have yielded a wealth of TF-binding datasets. ![]() CREs are often cell-type-specific and consist of specific TF-binding site (TFBS) combinations. Similar content being viewed by othersĬell identity is encoded by gene regulatory networks (GRNs), in which transcription factors (TFs) interact with sets of cis-regulatory elements (CREs) to control transcription of target genes. Finally, we use SCENIC+ to study the dynamics of gene regulation along differentiation trajectories and the effect of TF perturbations on cell state. Next, we exploit SCENIC+ predictions to study conserved TFs, enhancers and GRNs between human and mouse cell types in the cerebral cortex. We benchmarked SCENIC+ on diverse datasets from different species, including human peripheral blood mononuclear cells, ENCODE cell lines, melanoma cell states and Drosophila retinal development. ![]() To improve both recall and precision of TF identification, we curated and clustered a motif collection with more than 30,000 motifs. SCENIC+ predicts genomic enhancers along with candidate upstream transcription factors (TFs) and links these enhancers to candidate target genes. Here we present a method for the inference of enhancer-driven GRNs, called SCENIC+. Joint profiling of chromatin accessibility and gene expression in individual cells provides an opportunity to decipher enhancer-driven gene regulatory networks (GRNs). 1/18/2024 0 Comments Chemdraw ultra 13![]() ![]() You need to get a new serial number and registration code.
1/18/2024 0 Comments Dying light 2 create a character![]() He's also scared to death of anything without a penis. Dude loves to get into arguments, but consistently makes arguments that oppose his previous positions, depending on his mood. Overall based on your previous responses to other comments i get the impression you want "realism" in your protagonists of fictional story's to which i must ask why? Please correct me if i have gained the wrong impression.Īrguing with Sparhawk and his ilk is pointless if you need any proof of that, just check his comment history. I don't enjoy raising this point but in the current crisis the death rate for women is almost half the male death rate, and therefor in a similar pandemic such as zombies a woman would more then probably find it less of a challenge to survive. I will concede my argument about female fitness if you could provide and unbiased source of evidence. If that's the only flaw in what i said then you clearly need to revise your argument and even if that were true its worth taking into account that this is a fictional scenario (zombies). And the rate of injuries for them in military recruiting process is three times higher then men. ![]() Because women lag behind men physically in the vast majority of cases. Maybe you need to hit the gym more or join the armed forces. Originally posted by Xstar:unfortunately all posts like this descend into ether your typical gamer guy going we don't need a female character and others going we would like the option. take the first women's 100 meters where the women competing all finished the race despite the false reporting of the press and in the process beat the current 100 meters world record. I imagine that a'lot of these men who don't want to loose there male protagonist have varied reasons but i suspect one may be they don't want to loose there male role model which is a bit unfair considering the other gender never gets roll models for this kind of stuff.Īdditionally anyone who complains about immersion should remember that thoughout history the few women who did physical activity outperform men. I'm not mentioning my gender for obvious reasons but an option to just change a skin like in games such as shadow of mordors options really helps and is honestly the bare minimum needed to help these people not feel alienated by games they enjoy. I hated the first games male only roll because i generally don't enjoy playing as a man. ![]() Originally posted by LastSinister:well this is a fun thread unfortunately all posts like this descend into ether your typical gamer guy going we don't need a female character and others going we would like the option. I'd say more, but the softcore furry porn profile picture gets the point across better than I ever could. I guess the upside of this pandemic is that you're mostly confined to your basements- thank god for social distancing. And I guarantee I won't see you complaining if some game comes out and the playable character's female only.Ĭhrist, I feel sorry for any of the women who have the misfortune of interacting with dudes like you in real life. And I'm not stopping you from thinking this, I'm just saying it's ridiculous. ![]() Techland's choice on what they want to do, not yours. There were a ♥♥♥♥ ton of voicelines for Crane in the first game, now imagine DL2. Then, most of all, pay millions for a voice actor to record a thousand more lines. Every piece of clothing that goes on the torso will have to be remodeled to accommodate for that, maybe even animations if arms can clip through it. And let's not forget the breasts, the portion you crave the most, seeming that you are begging to play as a woman. Therefore you would have to at least adjust every single piece of clothing the character could wear to fit for both body types. An "ideal" female body is skinnier than the "ideal" male body. There is no excuse, nor justification, for not having a female voice actor say the same lines, and little to no reanimation necessary. Originally posted by Legerdemain:The effort required is minimal compared to virtually any other feature of the game, and Mass Effect (as well as numerous other games, like The Division) demonstrated just how seamless the difference can be. ![]() ![]() Model number and date introduced: A1238: September 2009 The Click Wheel's button labels, which are on the wheel itself The Hold switch, which is on the top-left side IPod mini is distinguished from other models by: Model number and date introduced: A1051: January 2004 The Click Wheel text color matches the color of the device The hard-drive size is engraved on back of the device You can distinguish the iPod mini (2nd generation) models from the original iPod mini models by: Model number and date introduced: A1051: February 2005 The capacity of the drive is engraved on the front USB connector. There are LED lights on the front and back. IPod shuffle is smaller than iPod mini and has no display. Model number and date introduced: A1112: January 2005 The last three characters of the serial number will be one of these: 1ZH, 1ZK, 1ZM, 1ZP, or 1ZR. IPod shuffle (2nd generation) is smaller than the original iPod shuffle and has no USB connector. Previous iPod shuffle generations had two. iPod shuffle (3rd generation) is smaller than the previous generations and has one status light. It has a clip similar to the iPod shuffle (2nd generation). This model has a headphone port that also connects to a computer's USB port. IPod shuffle (3rd generation) includes a single 3-position switch that toggles between off, play in order, and shuffle similar to the original iPod shuffle. Model number and date introduced: A1271: March 2009 ![]() The iPod shuffle (3rd generation Late 2009) also comes in a Special Limited Edition 4 GB model only available from the Apple Store. Model number and dates introduced: A1446: July 2015 You can also search, preview, and buy songs from the iTunes Wi-Fi Music Store on iPod touch. You can browse the web with Safari and watch YouTube videos on the first-ever Wi-Fi iPod. IPod touch features a 3.5-inch (diagonal) widescreen Multi-Touch display and 8 GB, 16 GB, or 32 GB flash drive. You can distinguish the iPod touch (2nd generation) from the previous model by its contoured design and oval shaped antennae cover in the back upper left corner. IPod touch (2nd generation) features a 3.5-inch (diagonal) widescreen Multi-Touch display and 8 GB, 16 GB, or 32 GB flash drive. iPod touch (2nd generation)Ī1319 for China mainland only: September 2008 In the text below the engraving, look for the model number. You can distinguish the iPod touch (3rd generation) from iPod touch (2nd generation) by looking at the back of the device. IPod touch (3rd generation) features a 3.5-inch (diagonal) widescreen Multi-Touch display and 32 GB or 64 GB flash drive. Model number and date introduced: A1318: September 2009 IPod touch (4th generation) is available in white and black. ![]() IPod touch (4th generation) has an iSight camera and FaceTime HD camera. This model is available in silver and has a FaceTime HD camera. Model number and date introduced: A1509: May 2013 iPod touch (5th generation 16 GB, Mid 2013) Songs from the Apple Music catalog cannot be burned to a CD.IPod touch (5th generation) is available in five colors. iTunes-compatible CD or DVD recorder to create audio CDs, MP3 CDs, or backup CDs or DVDs.Internet connection to use Apple Music, the iTunes Store, and iTunes Extras.Screen resolution of 1024x768 or greater 1280x800 or greater is required to play an iTunes LP or iTunes Extras.To play 1080p HD video, a 2.4GHz Intel Core 2 Duo or faster processor, 2GB of RAM, and an Intel GMA X4500HD, ATI Radeon HD 2400, or NVIDIA GeForce 8300 GS or better is required.To play 720p HD video, an iTunes LP, or iTunes Extras, a 2.0GHz Intel Core 2 Duo or faster processor, 1GB of RAM, and an Intel GMA X3000, ATI Radeon X1300, or NVIDIA GeForce 6150 or better is required.To play standard-definition video from the iTunes Store, an Intel Pentium D or faster processor, 512MB of RAM, and a DirectX 9.0–compatible video card is required.PC with a 1GHz Intel or AMD processor with support for SSE2 and 512MB of RAM. 1/18/2024 0 Comments Scroll to top bootstrap studio![]() To use clickable elements within the accordion, you have to override the accordion-group template to use div elements instead of anchor elements, and add cursor: pointer in your CSS. ![]() If you're using a custom template for the uib-accordion-group, you'll need to have an element for the heading to be transcluded into using uib-accordion-header (e.g. Instead of the heading attribute on the uib-accordion-group, you can use an uib-accordion-heading element inside a group that will be used as the group's header. Template-url (Default: uib/template/accordion/accordion-group.html). Whether accordion group is open or closed. Whether the accordion group is disabled or not. You need one to be able to click on the header for toggling. The clickable text on the group's header. Template-url (Default: template/accordion/accordion.html) -Īdd the ability to override the template used on the component. uib-accordion settingsĬontrol whether expanding an item will cause the other items to close. The body of each accordion group is transcluded into the body of the collapsible element. The accordion directive builds on top of the collapse directive to provide a list of items, with collapsible bodies that are collapsed or expanded by clicking on the item's header. * Some directives have a config service that follows the next pattern: uibDirectiveConfig. If the expression support a boolean / integer, you can pass it directly.įor the services (you will recognize them with the $ prefix), we list all the possible parameters you can pass to them and their default values if any. $ - This setting expects an angular expression instead of a literal string.C - This setting can be configured globally in a constant service*.- This setting has an angular $watch listener applied to it.In addition to this, some settings have a badge on it: Reading the documentationĮach of the components provided in ui-bootstrap have documentation and interactive Plunker examples.įor the directives, we list the different attributes with their default values. Please check our FAQ section for common problems / solutions. The remedy is simple, just add the following styling to your application. This is why we need to remove empty href attributes from directive templates and as a result styling is not applied correctly. Original Bootstrap's CSS depends on empty href attributes to style cursors for several components (pagination, tabs etc.).īut in AngularJS adding empty href attributes to link tags will cause unwanted route changes. If you are upgrading from ui-bootstrap 0.13.4 or earlier, Since version 0.14.0 we started to prefix all our components. You can fork one of the plunkers from this page to see a working example of what is described here. in an extension, make sure you link to the ui-bootstrap-csp.css in your HTML manually. If you are using UI Bootstrap in the CSP mode, e.g. Whichever method you choose the good news that the overall size of a download is fairly small:ġ22K minified for all directives with templates and 98K without (~31kB with gzipĬompression, with templates, and 28K gzipped without) InstallationĪs soon as you've got all the files downloaded and included in your page you just need to declareĪngular.module('myModule', ) For more information, check out the FAQ here and the README here.Īlternativelly, if you are only interested in a subset of directives, you can It should be noted that the -tpls files contain the templates bundled in JavaScript, while the regular version does not contain the bundled templates. All the options are described and can beĭownloaded from here. ![]() This version of the library (2.5.0) works only with Bootstrap CSS in version 3.x.Ġ.8.0 is the last version of this library that supports Bootstrap CSS in version 2.3.x.īuild files for all directives are distributed in several flavours: minified for production usage, un-minifiedįor development, with or without templates. Bootstrap CSS (tested with version 3.3.7).Angular-touch (the version should match with your angular's, tested with 1.6.1) if you plan in using swipe actions, you need to load angular-touch as well. ![]()
![]() Include SQLite 3.27.1 instead of SQLite 3.26.0.Initial fix for Dark mode problem on macOS Mojave ( #1751, c7dd272).Class ‘NullLineEdit’ lacks Q_OBJECT macro ( #1740).It’s not possible to modify some tables ( #1733).Allow bottom editor of Execute SQL tab to grow taller ( #1670). ![]() About Info - display 32bit vs 64bit ( #1660).“determining row count” displays forever in Browse Data tab ( #1654).Network inaccessible error when using a WiFi network ( #1595). ![]()
1/17/2024 0 Comments Jetblue mint routes![]() A full list of routes and openings have been posted as part of JetBlue’s announcement. JetBlue’s initial route openings from Newark and JFK will go into effect on June 13th, while later routes will open on a rolling basis from August 6th through October 1st. Adara data suggest that a disproportionate volume of that recovered traffic is from the leisure segment. Going forward, it will operate select flights between New York JFK and LAX over the coming weeks. The airline has flown the new aircraft from New York to Los Angeles, with the first flight departing at 10:30 ET this morning. The carrier follows most legacy airlines in returning some mothballed aircraft to the sky following an uptick in demand according to TSA data, passenger volumes are back at around 20% of year-over-year volume following a drop to around 5%. JetBlue’s A321neo, equipped with the all-new Mint product, has entered domestic service today. To open up all of the routes, JetBlue will pull several of its aircraft parked during the coronavirus out of storage. Later in the summer, JetBlue will continue opening new routes from JFK, Newark, LaGuardia and Philadelphia to destinations primarily served by the leisure market. In short: The new JetBlue mint is far superior to its predecessor, and far superior in both price and quality to lots of competing airlines.In addition, some destinations put on hold due to the coronavirus pandemic including Aguadilla, Martha’s Vineyard and Nantucket will reopen. The drink selection is equally impressive: artisanal seasonal cocktails, espresso from Brooklyn Roasters, and tea from Teapigs makes JetBlue Mint better than many New York City restaurants when it comes to quality and service. Served tapas style, you can choose 3-5 plates. ![]() With one of the most robust in-flight entertainment systems in the skies, plus Tuft & Needle bedding, food from New York-based Delicious Hospitality Group (the people behind Pascale Jones), you won’t get a better meal in the skies. If you want to rest and avoid possible smells from the bathroom, opt for rows 4 or 5 when doing the red eye. Row 8 is a little close to the lavatories, while row 2 is right by the airline staff busily working. 1 likes, 0 comments - ittn.ie on December 8, 2023: ' ITTN’s Supplier Spotlight is on jetblue From March 2024, JetBlue will be operating it. This comes at an extra cost ($199), but worth it for longer trips. If you’re on the hunt for the utmost personal space, something all of us could use a little more of in these post-pandemic times, you’ll want to reserve one of the two “studios” in the bulkhead row 1. The throne seats are definitely the best in this configuration, as you don’t have a seatmate, and have a ton of. This includes a staggered configuration, with three rows having seats in a 2-2 configuration, and two rows having seats in a 1-1 configuration. Thanks to the 1-1 arrangement, the new Mint is a truly private and spacious experience. JetBlue’s Mint cabin consisting of 16 seats. With its introduction of lie-flat seats and the expansion to transatlantic routes like. JetBlue Mint has significantly raised the bar in premium air travel, especially on routes where competitors like American Airlines and Alaska Airlines previously offered only recliner seats. Oh how the times–or rather JetBlue Mint–has changed. Business Class Offerings From Other Airlines. (You may recall the original JetBlue biz class cabin, where only 4 lucky flyers scored a private suite). Just when you thought the business class experience couldn’t get any more luxe: the next generation of JetBlue Mint gives everyone a private suite with a sliding door. The airline’s new LaGuardia destinations include: Birmingham. 2K for nonstop business class to London on JetBlue Mint? Roundtrip? We’ll take it.īut, before you get too excited, it is worth noting that Mint routes are limited: San Francisco, Aruba, London, and Los Angeles are the most popular destinations from New York, but bear in mind Gatwick and Heathrow are the only airports they fly to in all of Europe. As we already told, JetBlue Mint Booking is available for the routes of Latin America, the Caribbean, and London as well. Starting on May 5, 2023, American is adding six routes from LaGuardia as part of this last round of Northeast-focused updates. And at a fraction of the price on other airlines…British Airways, United, and Delta should be a bit concerned by this new fan favorite airline. In the last year or so, JetBlue’s Business Class programming has swept the elite travel world by storm, giving all major airlines a run for their money. ![]() In a message to crewmembers this week the carrier indicated it will extend some of the market suspensions put in place earlier this year for the fall season and into early 2023. But the company anticipates a bit of turbulence along the way. Welcome to the suite life–and no, we aren’t referring to hotel living. New planes are on the way, and JetBlue plans to resume growth in 2023. ![]() ![]() The intuitive controls and visual feedback ensure that users can easily navigate and dial in the desired settings, fostering a seamless creative workflow. One of the standout features of Martinic AXFX is its user-friendly interface, making it accessible to both seasoned professionals and aspiring musicians. Whether recreating the ambiance of a classic recording studio or experimenting with unique sonic textures, Martinic AXFX provides a sonic playground for those who appreciate the timeless charm of vintage audio equipment. Users can expect to find a range of vintage-inspired effects that add warmth, depth, and richness to their audio projects. The suite comprises a carefully curated selection of classic audio effects, each meticulously crafted to capture the nuances and character of the analog era. From lush reverbs to warm choruses and dynamic filters, Martinic AXFX encapsulates the essence of vintage sound processing, offering a versatile toolkit for creative sonic exploration. This comprehensive plugin effects suite is designed to cater to the discerning needs of musicians and producers seeking to infuse their audio productions with classic tones and textures reminiscent of iconic analog gear. Martinic AXFX stands as a testament to Martinic’s commitment to delivering high-quality vintage-inspired audio tools. Download Martinic AXFX Latest Version Free.What are the best alternatives to Martinic AXFX?.What is main advantages of Martinic AXFX used for?.What is the Latest Version of the Martinic AXFX?.Technical Details of Martinic AXFX for Mac.Features of Martinic AXFX 2024 for MacOSX. 1/17/2024 0 Comments Industrial designer jobs new york![]() Strong understanding of the Disney Brand.3+ years’ experience in the off-price retail market.Proficient in 3D Design Software, CAD, Photoshop & Illustrator is Required.Keep the manager informed of the status of all projects.Work Directly with Art Director, Merchandising Managers, and Creative Team.Produce Print-Ready Files and Tech Packs.Strong Command of Visual Design Capabilities, Including Composition, Layout, Hierarchy, Typography, and Color Judgement.Ability to use style guidance and apply it to components. Around the globe, we work with exceptional people, the latest and greatest tech and leading companies across industries to create value for our clients, people.Ability to Conceptualize, Design and Execute Unique/Trendy Packaging for our Products The average Industrial Designer I salary in New York, NY is 75,681 as of October 25, 2023, but the range typically falls between 68,242 and 85,412.The Graphic & Packaging Designer will be responsible for the designing, creation, and packaging development for at-home fragrances (candles, lanterns, packaged sets) for major retailers Please send a detailed resume and portfolio for review.Graphic & Packaging Designer- Home Fragrance View all Revlon jobs in New York, NY - New York jobs - Industrial Designer jobs in New York, NY Salary Search: Designer, Industrial salaries in New York, NY See popular questions & answers about Revlon Associate Industrial Designer. Position is based in Secaucus, NJ but travel to regional and national showrooms will be required. Senior Product Designer, Appointments (Onboarding & Growth). Adobe Suite skills plus Rhino are essential, as well as an elevated taste level, strong project organization skills and a willingness to get hands dirty while onsite. Qualified candidates must have a relevant 4-year degree and a minimum of 3 years hands-on experience in the areas of Architectural, Industrial or Furniture Design. ![]() Position involves developing and project managing luxury interior spaces for a variety of retail settings, from development through to on-site execution, including situations involving assembly and installation. 848 Industrial Designer Jobs in New York, NY Industrial Designer/Metal Fabrication Studio Assistant Creative Metal Fabrication New York, NY Remote 25 - 30 / hr Part-Time Creative Metal Fabrication located in East Williamsburg, Brooklyn is in need of an industrial designer fluid in Fusion 360. The low-stress way to find your next industrial designer job opportunity is on SimplyHired. Leverage your professional network, and get hired. New industrial designer careers in new york, ny are added daily on . Today’s top 1,000+ Industrial Design jobs in New York, United States. See salaries, compare reviews, easily apply, and get hired. design, application and sale of systems, controls, parts, and services for commercial, industrial. Leverage your professional network, and get hired. 32 industrial designer jobs available in new york, ny. A 12-week internship program that will challenge and develop your technical, business, sales. Today’s top 500 Freelance Industrial Designer jobs in New York, United States. Revlon New York, NY At Revlon, we create beauty innovations for everyone that inspire confidence and ignite joy every day. Artistic Tile is seeking a talented Industrial, Architectural or Furniture Designer with excellent creative, organizational, and technical skills to join our Visual Merchandising and Display team. New Freelance Industrial Designer jobs added daily. |
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